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L’expertise de l’INERIS en toxicocinétique

Abstract : The toxicokinetics (or pharmacokinetics) of a substance are a quantitative description of the set of absorption, distribution, elimination or metabolic steps that lead from an applied dose to an effective or toxic dose in target organs of the body. It is easy to imagine to what extent pharmacokinetics condition the toxicity of a given chemical. For example, no absorption or rapid elimination lead to reduced risks of toxicity. INERIS’ expertise and know-how in this field have recently been the object of several (pre-)regulatory applications: Technical support of REACH, quantification of uncertainty and variability in risk assessments, definition of toxicological reference values and support with regard to the regulation of mixtures of substances.
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Submitted on : Thursday, September 6, 2018 - 11:19:45 AM
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  • HAL Id : ineris-01869084, version 1



Frédéric Y. Bois. L’expertise de l’INERIS en toxicocinétique. Rapport Scientifique INERIS, 2007, 2006-2007, pp.37-38. ⟨ineris-01869084⟩



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