HAL will be down for maintenance from Friday, June 10 at 4pm through Monday, June 13 at 9am. More information
Skip to Main content Skip to Navigation
Journal articles

Biodistribution et élimination de nanotubes de carbone instillés dans les poumons de rats

Abstract : Background: Constituted only by carbon atoms, CNT are hydrophobic and hardly detectable in biological tissues. These properties make biokinetics and toxicology studies more complex. Methods: We propose here a method to investigate the biopersistence of CNT in organism, based on detection of nickel, a metal present as trace in the NTC we investigated. Results and conclusion: Our results in rats that received NTC by intratracheal instillation, reveal that NTC can be eliminated and do not significantly cross the pulmonary barrier but are still present in lungs 6 months after a unique instillation. NTC structure was also showed to be chemically modified and cleaved in the lung. Long-time presence of NTC in the lung is associated with lung induction of cytochrome P450 1A1 and 2E1 mRNA suggesting a possible role of these enzymes in NTC clearance. These results provide the first data of CNT biopersistence and clearance at 6 month after respiratory administration.
Document type :
Journal articles
Complete list of metadata

https://hal-ineris.archives-ouvertes.fr/ineris-01869276
Contributor : Gestionnaire Civs Connect in order to contact the contributor
Submitted on : Thursday, September 6, 2018 - 1:12:35 PM
Last modification on : Thursday, September 6, 2018 - 1:12:35 PM
Long-term archiving on: : Friday, December 7, 2018 - 11:57:21 PM

File

2010-462.pdf
Publication funded by an institution

Identifiers

  • HAL Id : ineris-01869276, version 1

Collections

Citation

Dan Elgrabli. Biodistribution et élimination de nanotubes de carbone instillés dans les poumons de rats. Rapport Scientifique INERIS, 2010, 2009-2010, pp.51-53. ⟨ineris-01869276⟩

Share

Metrics

Record views

29

Files downloads

15