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Biodistribution et élimination de nanotubes de carbone instillés dans les poumons de rats

Abstract : Background: Constituted only by carbon atoms, CNT are hydrophobic and hardly detectable in biological tissues. These properties make biokinetics and toxicology studies more complex. Methods: We propose here a method to investigate the biopersistence of CNT in organism, based on detection of nickel, a metal present as trace in the NTC we investigated. Results and conclusion: Our results in rats that received NTC by intratracheal instillation, reveal that NTC can be eliminated and do not significantly cross the pulmonary barrier but are still present in lungs 6 months after a unique instillation. NTC structure was also showed to be chemically modified and cleaved in the lung. Long-time presence of NTC in the lung is associated with lung induction of cytochrome P450 1A1 and 2E1 mRNA suggesting a possible role of these enzymes in NTC clearance. These results provide the first data of CNT biopersistence and clearance at 6 month after respiratory administration.
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https://hal-ineris.archives-ouvertes.fr/ineris-01869276
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  • HAL Id : ineris-01869276, version 1

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Dan Elgrabli. Biodistribution et élimination de nanotubes de carbone instillés dans les poumons de rats. Rapport Scientifique INERIS, 2010, 2009-2010, pp.51-53. ⟨ineris-01869276⟩

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