La cytométrie de flux, un outil innovant en écotoxicologie

Abstract : Flow cytometry is a technique for counting and examining microscopic particles, such as cells, in a simultaneous multiparametric analysis of the physical and/or chemical characteristics. Currently, flow cytometry is used in the diagnosis of health disorders, but has many other applications in both research and clinical practice. In fact, some laboratories used flow cytometer for biomonitoring of organism health and risk assessment. Thus, a flow cytometry platform was purchased by the INERIS Institute to use it in several projects, such as DEVIL (Development and validation of fish biomarkers for the implementation of environmental legislation). The immune capacities were now routinely performed ex vivo, in vivo and in situ in the Institute. In the same way, other scopes of applications were proposed, such as genotoxicity in rats and three-spined sticklebacks; toxicity in human cultured cells and algae. All these studies enable using of flow cytometry for risk assessment by ecotoxicological, toxicological and biomonitored experiments.
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Anne Bado-Nilles, Wilfried Sanchez. La cytométrie de flux, un outil innovant en écotoxicologie. Rapport Scientifique INERIS, 2011, 2010-2011, pp.66-68. ⟨ineris-01869393⟩

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