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Bioanalyse des perturbateurs endocriniens dans les milieux aquatiques

Abstract : Mechanism-based in vitro and in vivo bioassays are increasingly used as part of integrated bio-analytical strategies, for the monitoring of both classical and emerging chemical contaminants in the aquatic environment. Here, we describe such an approach based on the combination of in vitro screening biological tools and physic-chemical methods and used to detect and identify endocrine disruptive chemicals (EDCs) in different environmental matrices such as effluents, sediment or surface waters. The developed approach is exemplified by the determination of steroid and xenobiotic activities profiles in various wastewater effluents and the further chemical identification of active compounds using bioassay-directed analysis. Eventually, the complementary use of innovative in vivo screening assays using zebrafish provide further useful information on the biological impact of active contaminants or samples, hence improving significantly chemical hazard assessment of analyzed samples.
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https://hal-ineris.archives-ouvertes.fr/ineris-01869423
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  • HAL Id : ineris-01869423, version 1

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Selim Ait-Aissa, Nicolas Creusot, Jean-Marc Porcher. Bioanalyse des perturbateurs endocriniens dans les milieux aquatiques. Rapport Scientifique INERIS, 2012, 2011-2012, pp.51-53. ⟨ineris-01869423⟩

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