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Génotoxicité et perturbation de la reproduction chez l’épinoche à trois épines

Abstract : Many environmental pollutants are genotoxicants and can induce genetic damages in wild organisms. If genetic damage occurs in somatic cells, deleterious effects are restricted to the exposed organisms but when it affects germ cells, it may increase the risk of progeny defects as clearly pointed out in humans and aquatic species. Hence, identification of genetic risks related to environmental genotoxicants is a crucial point. In this context, INERIS and the UMR 5023 of the University of Lyon investigate the relationship between DNA damage of germ cells and progeny survival or development abnormalities. For this purpose, the threespined stickleback is used as model fish species. Ex vivo and in vivo experiments highlight that exposure to MMS, a model genotoxicant, affects significantly sperm DNA integrity and increases mortality during embryo-larval stages and abnormality rate at hatching. Field studies were also performed to address this relationship in wild sticklebacks but further studies are needed to confirm the ecological relevance of this hypothesis.
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Submitted on : Thursday, September 6, 2018 - 2:52:31 PM
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  • HAL Id : ineris-01869455, version 1



Wilfried Sanchez. Génotoxicité et perturbation de la reproduction chez l’épinoche à trois épines. Rapport Scientifique INERIS, 2013, 2012-2013, pp.30-31. ⟨ineris-01869455⟩



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