Effet d'une exposition répétée au dioxyde d'azote et/ou à des nanoparticules de carbone sur la fonction pulmonaire, la réactivité bronchique et l’inflammation chez le rat sensibilisé à l'ovalbumine

Abstract : The interaction of particulate and gaseous pollutants in their effects on the severity of allergic inflammation and airway responsiveness are not well understood. We assessed the pulmonary effects of exposure to NO2 in the presence or absence of repetitive treatment with carbon nanoparticle (CNP) during allergen (ovalbumin) sensitization and challenges in Brown- Norway (BN) rats. groups of control and OVA-sensitized rats were exposed to NO2 (10 ppm, 6 h / d, 5d / 7) for 4 weeks, to CNP (Degussa-FW2, 13 nm) or to both pollutants. Our results show that NO2 exposure significantly increases lung inflammation, airway responsiveness, and expression of Th2-type cytokines in sensitized animals. CNP led only to lung inflammation, and expression of Th1 cytokines, without significant change in bronchial reactivity. Sensitized animals simultaneously exposed to NO2 and CNP had a less pronounced airway hyperresponsiveness than those exposed to NO2 alone, and decreased Th2 cytokines. We conclude that exposure to CNP could have an immunomodulatory effect on inflammation induced by NO2 exposure in allergen-sensitized BN rats.
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Ghislaine Lacroix. Effet d'une exposition répétée au dioxyde d'azote et/ou à des nanoparticules de carbone sur la fonction pulmonaire, la réactivité bronchique et l’inflammation chez le rat sensibilisé à l'ovalbumine. Rapport Scientifique INERIS, 2013, 2012-2013, pp.41-42. ⟨ineris-01869459⟩

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