Évaluation de l’exposition des femmes enceintes françaises aux phtalates

Abstract : The ubiquitous use of phthalate esters in plastics, building materials, medical devices, personal care products and food packaging materials results in widespread general population exposure. This study reports measurements of urinary concentration of phthalate metabolites in France and provides the first exposure assessment of French pregnant women to these compounds. For most of the phthalate metabolites, concentrations measured in urine were similar to those reported in previous studies except for two phthalates: High levels of DiNP (Di-iso-nonylphthalate) and DEHP (Di (2-ethylhexyl) phthalate) metabolites compared to other European and American studies were observed. In a second part of the study, a pharmacokinetic model was used in order to better understand the exposure to DEHP. A high concentration of the primary metabolite of DEHP was identified in this case, with a suspicion of very recent exposure in hospital due to perfusion materials. The pharmacokinetic modelling highlighted the importance of information availability about the time between exposure and biomonitoring measurements for non-persistent pollutants.
Document type :
Journal articles
Complete list of metadatas

https://hal-ineris.archives-ouvertes.fr/ineris-01869494
Contributor : Gestionnaire Civs <>
Submitted on : Thursday, September 6, 2018 - 3:04:09 PM
Last modification on : Friday, September 7, 2018 - 1:11:29 AM
Long-term archiving on : Friday, December 7, 2018 - 6:54:08 PM

File

2014-463.pdf
Publication funded by an institution

Identifiers

  • HAL Id : ineris-01869494, version 1

Collections

Citation

Céline Boudet, Karine Tack, Céline Brochot, Florence Zeman. Évaluation de l’exposition des femmes enceintes françaises aux phtalates. Rapport Scientifique INERIS, 2014, 2013-2014, pp.22-23. ⟨ineris-01869494⟩

Share

Metrics

Record views

543

Files downloads

60