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Journal articles

Évaluation de l’exposition des femmes enceintes françaises aux phtalates

Abstract : The ubiquitous use of phthalate esters in plastics, building materials, medical devices, personal care products and food packaging materials results in widespread general population exposure. This study reports measurements of urinary concentration of phthalate metabolites in France and provides the first exposure assessment of French pregnant women to these compounds. For most of the phthalate metabolites, concentrations measured in urine were similar to those reported in previous studies except for two phthalates: High levels of DiNP (Di-iso-nonylphthalate) and DEHP (Di (2-ethylhexyl) phthalate) metabolites compared to other European and American studies were observed. In a second part of the study, a pharmacokinetic model was used in order to better understand the exposure to DEHP. A high concentration of the primary metabolite of DEHP was identified in this case, with a suspicion of very recent exposure in hospital due to perfusion materials. The pharmacokinetic modelling highlighted the importance of information availability about the time between exposure and biomonitoring measurements for non-persistent pollutants.
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Submitted on : Thursday, September 6, 2018 - 3:04:09 PM
Last modification on : Thursday, March 10, 2022 - 2:02:05 PM
Long-term archiving on: : Friday, December 7, 2018 - 6:54:08 PM


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  • HAL Id : ineris-01869494, version 1



Céline Boudet, Karine Tack, Céline Brochot, Florence Zeman. Évaluation de l’exposition des femmes enceintes françaises aux phtalates. Rapport Scientifique INERIS, 2014, 2013-2014, pp.22-23. ⟨ineris-01869494⟩



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