Le projet européen HELIX : exposome et modélisation toxicocinétique

Abstract : Developmental periods in early life may be particularly vulnerable to impacts of environmental exposures. Human research on this topic has generally focused on single exposure-health effect relationships. The Human Early-Life Exposome (HELIX) project is a collaborative research project (2013-2017) that aims to implement novel exposure assessment and biomarker methods to characterize early-life exposure to multiple environmental factors and associate these with omics biomarkers and child health outcomes, thus characterizing the “early-life exposome” (i. e. the totality of exposures from conception). HELIX is one of the first attempts to describe the early-life exposome of European populations and unravel its relation to omics markers and health in childhood. As proof of concept, it will form an important first step toward the life-course exposome. Within the HELIX project, we aim to apply toxicokinetic models to evaluate the exposure of fetus and children, and to interpret the biomarker measurements in terms of internal exposure in the target tissues during the critical time periods using toxicokinetic modeling.
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Florence Zeman, Céline Brochot. Le projet européen HELIX : exposome et modélisation toxicocinétique. Rapport Scientifique INERIS, 2015, 2014-2015, pp.34-35. ⟨ineris-01869530⟩

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