Profilage de la toxicité de nouvelles substances par méthodes alternatives

Abstract : Toxicology is changing its experimental approaches from animal testing to less expensive, more ethical and relevant methods. Modern toxicology relies on two main components : in vitro testing and in silico analyses. Toxicology has also entered a world of “big data” production, switching from a low-throughput to a high-throughput mode of screening. The DRC/VIVA/ METO unit of INERIS is spearheading the development of the methods and models needed to extrapolate the results of in vitro assays to in vivo human exposures. The key ingredients of our approach are physiological pharmacokinetic (PBPK) models, systems biology models of adverse outcome pathways (AOP) and Bayesian methods for statistical inference and uncertainty reduction. In the framework of large European projects such as PREDICT-IV, COSMOS, StemBANCC, EU-ToxRisk and Euromix, METO actively transfers its results to university and chemical, cosmetic or pharmaceutical industry partners.
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Frédéric Y. Bois. Profilage de la toxicité de nouvelles substances par méthodes alternatives. Rapport Scientifique INERIS, 2016, 2015-2016, pp.52-53. ⟨ineris-01869629⟩

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