Les progestatifs, les poissons et les milieux aquatiques : apports du projet ANR « proofs »

Abstract : During the past twenty years, numerous studies have examined the effects of estrogenic compounds, notably 17α-ethinylestradiol a potent synthetic steroidal estrogen used as pharmaceuticals in contraceptive pills, because these substances were among the first identified as endocrine disrupting compounds responsible for the feminization of wild populations of fish observed worldwide. There is now evidence of the occurrence of other natural and synthetic steroids in aquatic environment. Among steroidal pharmaceuticals, the risks encountered by synthetic progestins on aquatic species have been recently pointed out but data on their occurrence and effects on fish endocrinology and physiology are missing to properly assess their hazard and risk to aquatic species. The national project ANR “PROOFS” aimed at investigating the effect of progestins on key molecular and cellular targets of the endocrine system using zebrafish in vitro and in vivo reporter gene mechanismbased assays. It also aimed at providing data on the occurrence of progestagenic activity of environmental samples and to identify substances responsible for these activities through an effectdirected analysis (EDA) approach. Among the 26 pharmaceutical progestins investigated, our data revealed that they can act on several steroidal nuclear receptors. By using novel transgenic zebrafish models, we demonstrated for the first time their estrogenic activity in the developing brain and their capacity to disrupt corticosteroigenesis in interrenal cells. Finally, we reported strong progestagenic activity in waste waters and identified several pharmaceuticals as potential candidate responsible for these activities. Overall, the ANR project “PROOFS” brings novel and relevant data on occurrence and endocrine potency of progestins stressing the need to further study these emerging contaminants
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François Brion, Clémentine Garoche, Nathalie Hinfray, Selim Ait-Aissa. Les progestatifs, les poissons et les milieux aquatiques : apports du projet ANR « proofs ». Rapport Scientifique INERIS, 2017, 2016-2017, pp.14-15. ⟨ineris-01869652⟩

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