Modéliser l’exposition environnementale et les imprégnations des populations à des substances chimiques : l’outil merlin-expo

Abstract : The 4FUN project funded under the European Union’s 7th Framework Programme produced a software, named MERLINExpo, containing a library of models for exposure assessment, coupling environmental multimedia and pharmacokinetic models. The main challenges in exposure modelling that MERLIN-Expo has tackled are: (a) the integration of multimedia models simulating the fate of chemicals in environmental media, and of physiologically based pharmacokinetic models simulating the fate of chemicals in human body. MERLIN-Expo thus allows the determination of internal effective chemical concentrations; (b) the incorporation of a set of functionalities for uncertainty/ sensitivity analysis, from screening to variance-based approaches. The availability of such tools for uncertainty and sensitivity analysis aimed to facilitate the incorporation of such issues in future decision making; (c) the integration of human and wildlife biota targets with common fate modelling in the environment. The models can be linked together to create flexible scenarios relevant for both human and wildlife biota exposure. Three case studies based on actual datasets were performed using MERLIN-Expo.
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Céline Brochot. Modéliser l’exposition environnementale et les imprégnations des populations à des substances chimiques : l’outil merlin-expo. Rapport Scientifique INERIS, 2017, 2016-2017, pp.56-57. ⟨ineris-01869670⟩

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