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Évaluation de la reproductibilité des approches « read across » entre évaluateurs

Abstract : The European LIFE project CALEIDOS succeeded in providing practical information on QSAR models and read-across approaches in the framework of the REACH regulation by conducting validation exercises on chemicals that were submitted to the European Chemicals Agency. This project also organized a round-robin exercise aimed at evaluating the reproducibility of toxicological predictions obtained by means of read-across approaches. Indeed, predictions obtained by read-across represent the most common alternative to animal testing reported in the dossiers submitted by registrants under the REACH regulation. Three endpoints were analysed during the exercise: mutagenicity, bioconcentration factor and fish acute toxicity. Nine chemicals were associated with each endpoint and the participants completed a questionnaire relating their conclusions. The final results suggest that the level of reproducibility changes according to the predicted endpoint and the computational tool adopted for obtaining the predictions. Overall this exercise indicates that there are several areas of uncertainty in read-across assessments and that there is a need to identify reproducible and robust arguments to substantiate read-across predictions.
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Submitted on : Thursday, September 6, 2018 - 3:51:19 PM
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  • HAL Id : ineris-01869673, version 1



Enrico Mombelli. Évaluation de la reproductibilité des approches « read across » entre évaluateurs. Rapport Scientifique INERIS, 2017, 2016-2017, pp.62-63. ⟨ineris-01869673⟩



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