Approches intégrant bioessais et analyses chimiques pour évaluer la qualité des milieux aquatiques

Abstract : Effect-based methods (EBM) are recognized as relevant tools to diagnose and monitor chemical contamination in aquatic systems, considering both known and unknown biologically active contaminants. Integrated strategies combining EBM and analytical tools are needed for holistic assessment of aquatic micropollutants and identification of causes of degraded water quality. Such an integrative approach has been developed at Ineris to assess environmental endocrine disruptive compounds (EDCs). By using a smart battery of in vitro (cellular assays) and in vivo (fish embryo) bioassays, we established contamination profiles of environmental matrices based on complementary bioassays that cover different modes of action of EDCs, while informing on their impact and general toxicity at the organism level in zebrafish embryos. Combining bioassays with analytical methods allows effect-directed identification of those compounds responsible for observed effects. Such an approach has been successfully applied in local case-studies, such as EDC hazard assessment and identification of glucocorticoid compounds in urban effluent, as well as in national and European demonstration studies
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Selim Ait-Aissa, François Bron. Approches intégrant bioessais et analyses chimiques pour évaluer la qualité des milieux aquatiques. Rapport Scientifique INERIS, 2018, 2017-2018, pp.54-55. ⟨ineris-02044874⟩

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