Intérêt des réponses immunitaires dans le cadre des études de biosurveillance

Abstract : Immune parameters are interesting in biomonitoring studies as they reflect environmental contamination and fish health status. Nevertheless, fish immunomarkers could be influenced by many environmental and interindividual parameters. All these confounding factors limit the interpretation of variation between sites and may disturb the routine environmental risk assessment. Characterizing the remaining natural sources of biomarker variability could allow discriminating responses induced by pollutant exposure and background noise. In this way, establishment of reference values, that consider the major sources of variation, may be of great interest for environmental monitoring studies. Moreover, connection has been established between the destabilization of the fish immune system caused by sublethal doses of contaminants and a defect in fish pathogen resistance. In this way, we proposed to develop a stress on stress responses by using some bacterial endotoxin, which mimic pathogen effect, and chemical exposure. This method can be a promising approach for the assessment of pollutant effects in aquatic ecosystems by determining biological threshold values. This biological threshold values could indicate the real capacity of fish to respond during pathogenic condition
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Anne Bado-Nilles, Jean-Marc Porcher, Adrien Marchand, Cyril Turies, Edith Chadili. Intérêt des réponses immunitaires dans le cadre des études de biosurveillance. Rapport Scientifique INERIS, 2018, 2017-2018, pp.56-57. ⟨ineris-02044875⟩

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