Evaluation of Inflammation by Cytokine Production Following Combined Exposure to Ultraviolet and Radiofrequency Radiation of Mobile Phones on 3D Reconstructed Human Skin In Vitro - Archive ouverte HAL Access content directly
Journal Articles International Journal of Environmental Research and Public Health Year : 2020

Evaluation of Inflammation by Cytokine Production Following Combined Exposure to Ultraviolet and Radiofrequency Radiation of Mobile Phones on 3D Reconstructed Human Skin In Vitro

(1) , (1) , (1) , (1) , (1) , (1) , (2, 3) , (1)
1
2
3

Abstract

The absorption of exposure to radiofrequency (RF) emitted by wireless devices leads to a high specific absorption rate in the skin. Ultraviolet (UV) radiation can induce several damages to the skin. The aim of this study was to examine whether combined, consecutive exposure to solar UV radiation and 1950 MHz RF exposure of third generation (3G) mobile system have any effect on inflammation processes in the skin. Under in vitro experiments, the inflammation process was examined by cytokines (IL-1α, IL-6, and IL-8) and MMP-1 enzyme secretion on 3D full thickness human skin model. The RF exposure was applied before or after UV irradiation, in order to study either the possible cooperative or protective effects of exposure to RF and UV. We did not find changes in cytokines due to exposure to RF alone. The RF exposure did not enhance the effects of UV radiation. There was a statistically not-significant decrease in cytokines when the skin tissues were pre-exposed to RF before being exposed to 4 standard erythemal dose (SED) UV compared to UV exposure alone. We found that RF exposure reduced the previously UV-treated MMP-1 enzyme concentration. This study might support the evaluation of the effects on the skin exposed to microwave radiation of 5G mobile technology.
Fichier principal
Vignette du fichier
2020-062.pdf (2.74 Mo) Télécharger le fichier
Origin : Publication funded by an institution

Dates and versions

ineris-03230215 , version 1 (19-05-2021)

Identifiers

Cite

Zsofia Szilagyi, Zsuzsanna Nemeth, Jozsef Bakos, Peter Pal Necz, Anna Safar, et al.. Evaluation of Inflammation by Cytokine Production Following Combined Exposure to Ultraviolet and Radiofrequency Radiation of Mobile Phones on 3D Reconstructed Human Skin In Vitro. International Journal of Environmental Research and Public Health, 2020, 17 (12), pp.4401. ⟨10.3390/ijerph17124401⟩. ⟨ineris-03230215⟩
154 View
40 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More