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Risk assessment of EDCs in Europe based on human biomonitoring data

Abstract : A major advantage of human biomonitoring (HBM) data is that they provide an integrated overview of the body burden to xenobiotics that an individual is exposed to. However, quantification of exposure based on HBM data poses significant challenges that are worth facing, given the opportunities that HBM provides in terms of informing and effectively supporting risk assessment. Based on the above, the aim of this within the HBM4EU project was to derive EU-wide external exposure estimates starting from HBM data and to derive and risk characterization ratio (RCR) by comparing these estimates with existing regulatory thresholds. For the reconstruction of exposure the INTEGRA computational platform was properly parameterised for the compounds of interest, namely bisphenol-A (BPA), phthalates (DEHP, DiNP and DnBP) and DINCH, emerging flame retardants (TCEP) and Perfluorinated compounds (PFOA and PFOS). The results indicated that for the majority of the examined compounds, daily intake levels are below the existing regulatory thresholds. For BPA, mean daily intake is almost 2 orders of magnitude below the respective threshold proposed by EFSA. For phthalates, daily intake estimates are usually one or two orders of magnitude below the respective TDI, with the exception of BBzP, for which intake estimates of the upper part of the exposure distribution is close to the threshold of 10 μg/kg_bw/d. Regarding TCEP, which is a typical emerging flame retardant, the mean daily intake estimate is below 0.1 μg/kg_bw/d, which is far below the calculated ‘provisional’ TDI of 13 μg/kg_bw/d, however, at the moment very few HBM data were available and these exposure levels are rather indicative than representative of the European countries. Finally, regarding the estimated intakes of PFCs, intake levels of PFOS are very close to TDI (0.15 μg/ kg_bw/d proposed by the CONTAM Panel), while the calculated levels for PFOA are one order of magnitude below the respective TDI of 1.5 μg/kg_bw/d.
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Submitted on : Wednesday, May 26, 2021 - 3:42:57 PM
Last modification on : Wednesday, May 26, 2021 - 3:42:59 PM

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D.A. Sarigiannis, Spryros Karakitsios, A. Gotti, V. Kumar, Michel Schuhmacher, et al.. Risk assessment of EDCs in Europe based on human biomonitoring data. 55. Congress of the European Societies of Toxicology (EUROTOX 2019), Sep 2019, Helsinki, Finland. pp.S295. ⟨ineris-03237279⟩

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