Toxicology and Biodegradability of a Phthalate-Free and Bio-Based Novel Plasticizer

S. Simar-Mentières (1) , F. Nesslany (1) , M.-L. Sola (2) , S. Mortier (2) , J.-M. Raimbault (2) , Franck Gondelle (3) , Laure Chabot (3) , Pascal Pandard (3) , D. Wils (4) , A. Chentouf (4)

1 Laboratoire de toxicologie génétique [Lille]
2 ERBC - European Research Biology Center
3 INERIS - Institut National de l'Environnement Industriel et des Risques
4 Roquette Frères

Phthalate esters, mainly di-ethylhexylphthalate (DEHP), represent a class of chemicals primarily used as plasticizers for polyvinyl chloride in a wide range of domestic and industrial applications. ese phthalate esters are low-toxicity environmental contaminants. To address these drawbacks, POLYSORB ® ID 37, a blend of diesters obtained from esterification of isosorbide with plant-based fatty acids, was developed. e company can now offer PVC manufacturers a new product which competes with phthalates and other such chemicals. e market for plasticizers is very important, and ROQUETTE intends to provide a more sustainable and safer product. Isosorbide diester is bio-based (made from glucose and vegetable fatty acids). is plasticizer is registered in REACH regulation for high volumes (>1000 T/year). Risk assessment was obtained by conducting a wide range of biodegradability and toxicological protocols, using rodent models, according to established guidelines. Overall, all of the toxicological and biodegradability studies demonstrated that POLYSORB ® ID 37 is nontoxic to mammalian life and is readily biodegradable.

Domaines: Toxicologie

S. Simar-Mentières, F. Nesslany, M.-L. Sola, S. Mortier, J.-M. Raimbault, et al.. Toxicology and Biodegradability of a Phthalate-Free and Bio-Based Novel Plasticizer. Journal of toxicology, 2021, 2021, pp.9970896. ⟨10.1155/2021/9970896⟩. ⟨ineris-03333614⟩