Skip to Main content Skip to Navigation
New interface
Journal articles

Integration of Genotoxic Biomarkers in Environmental Biomonitoring Analysis Using a Multi-Biomarker Approach in Three-Spined Stickleback (Gasterosteus aculeatus Linnaeus, 1758)

Abstract : Water is impacted by a variety of increasing pressures, such as contaminants, including genotoxic pollutants. The proposed multi-biomarker approach at a sub-individual level gives a complementary indicator to the chemical and ecological parameters of the Water Framework Directive (WFD, 2000/60/EC). By integrating biomarkers of genotoxicity and erythrocyte necrosis in the sentinel fish species the three-spined stickleback (Gasterosteus aculeatus) through active biomonitoring of six stations of the Artois-Picardie watershed, north France, our work aimed to improve the already existing biomarker approach. Even if fish in all stations had high levels of DNA strand breaks, the multivariate analysis (PCA), followed by hierarchical agglomerative clustering (HAC), improved discrimination among stations by detecting an increase of nuclear DNA content variation (Etaing, St Rémy du Nord, Artres and Biache-St-Vaast) and erythrocyte necrosis (Etaing, St Rémy du Nord). The present work highlighted that the integration of these biomarkers of genotoxicity in a multi-biomarker approach is appropriate to expand physiological parameters which allow the targeting of new potential effects of contaminants.
Complete list of metadata

https://hal-ineris.archives-ouvertes.fr/ineris-03824416
Contributor : Gestionnaire Civs Connect in order to contact the contributor
Submitted on : Friday, October 21, 2022 - 4:00:31 PM
Last modification on : Saturday, October 22, 2022 - 5:41:22 AM

File

2022-030.pdf
Publication funded by an institution

Identifiers

Citation

Amélie Cant, Marc Bonnard, Jean-Marc Porcher, Jean Prygiel, Audrey Catteau, et al.. Integration of Genotoxic Biomarkers in Environmental Biomonitoring Analysis Using a Multi-Biomarker Approach in Three-Spined Stickleback (Gasterosteus aculeatus Linnaeus, 1758). Toxics, 2022, 10 (3), pp.101. ⟨10.3390/toxics10030101⟩. ⟨ineris-03824416⟩

Share

Metrics

Record views

0

Files downloads

0