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rbioacc: An R-package to analyze toxicokinetic data

Abstract : The R-package rbioacc allows to analyse experimental data from bioaccumulation tests where organisms are exposed to a chemical (exposure) then put into clean media (depuration). Internal concentrations are measured over time during the experiment. rbioacc provides turnkey functions to visualise and analyse such data. Under a Bayesian framework, rbioacc fits a generic one-compartment toxicokinetic model built from the data. It provides TK parameter estimates (uptake and elimination rates) and standard bioaccumulation metrics. All parameter estimates, bioaccumulation metrics and predictions of internal concentrations are delivered with their uncertainty. Bioaccumulation metrics are provided in support of environmental risk assessment, in full compliance with regulatory requirements required to approve market release of chemical substances. This paper provides worked examples of the use of rbioacc from data collected through standard bioaccumulation tests, publicly available within the scientific literature. These examples constitute step-by-step user-guides to analyse any new data set, uploaded in the right format.
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https://hal-ineris.archives-ouvertes.fr/ineris-03846876
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Submitted on : Monday, November 21, 2022 - 2:49:23 PM
Last modification on : Tuesday, November 22, 2022 - 3:22:49 AM

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Aude Ratier, Virgile Baudrot, Miléna Kaag, Aurélie Siberchicot, Christelle Lopes, et al.. rbioacc: An R-package to analyze toxicokinetic data. Ecotoxicology and Environmental Safety, 2022, 242, pp.113875. ⟨10.1016/j.ecoenv.2022.113875⟩. ⟨ineris-03846876⟩

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