Repetitive exposure to low-intensity radiofrequency fields changes the sensitivity of TRPM8 to its antagonists

Jennifer Maalouf (1, 2) , René de Seze (1, 2)

1 INERIS - Institut National de l'Environnement Industriel et des Risques
2 PERITOX - Périnatalité et Risques Toxiques - UMR INERIS_I 1

The involvement of TRPM8, the main cold-sensitive receptor, by injecting its specific antagonist, AMG2850, shows a decrease in body and peripheral temperatures in control animals (without RF exposure) while, injection of the antagonist AMG2850, did not induce a decrease in temperature in animals exposed to RF. This suggests that the TRPM8 receptors of the exposed animals are no longer sensitive to the antagonist after exposure to RF The objective of the present study was to investigate the specificity of the antagonist on TRPM8 effect, the impact of RF on thermal receptors TRPM2, TRPM5, TRPV1, TRPV4, on thermogenic 366 organs (white fat, liver, thyroid…) and on thermoregulatory biomolecular pathways.

Domains: Toxicology

Jennifer Maalouf, René de Seze. Repetitive exposure to low-intensity radiofrequency fields changes the sensitivity of TRPM8 to its antagonists. Annual meeting of the Bioelectromagnetics Society and the European BioElectromagnetics Association (BioEM 2022), Jun 2022, Nagoya, Japan. ⟨ineris-03899792⟩