Browning of white adipose tissue after repeated low power RF exposure

René de Seze (1, 2) , Amandine Pelletier (2) , Thi Cuc MAI (1, 2)

1 INERIS - Institut National de l'Environnement Industriel et des Risques
2 PERITOX - Périnatalité et Risques Toxiques - UMR INERIS_I 1

After a repeated exposure to low power radiofrequency electromagnetic fields (RF), mice and rats showed thermoregulatory changes mimicking reactions to cold. Body temperature patterns in mice, measured by telemetry transmitters, changed synchronously with the RF exposure periods after 3 days. The shown episodes of quick temperature increase lead us to consider brown adipose tissue as an effector, but inguinal white adipose tissue was also analyzed for comparison. Strikingly, like responses to cold stimuli, both exposed rats and mice showed changes in the morphology of white and brown adipocytes. Exposure also led to a larger plasma concentration of non-esterified fatty acids (NEFA), a marker of lipolysis in non-shivering thermogenesis.

Domaines: Toxicologie

René de Seze, Amandine Pelletier, Thi Cuc MAI. Browning of white adipose tissue after repeated low power RF exposure. Annual meeting of the Bioelectromagnetics Society and the European BioElectromagnetics Association (BioEM 2021), Sep 2021, Ghent, Belgium. ⟨ineris-03899866⟩