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Etude comparative sur les performances et l'ergonomie de nébuliseurs dans la mucoviscidose

Abstract : This study had, as its aim, to lest twelve nebulizers (6 jet, 6 ultrasonic) which are used in the treatment of cystic fibrosis. Devices were connected to a respirator in order to mimic the Ventilation of a child and of an adult suffering from cystis fibrosis. Three medications : tobramycine, colistine and amiloride were nebulised. The volume of the recommended solution varied between 1.5 and 13 ml according to the manufacturer. During a Session of ten minutes the ultrasonic nebulizer delivered an inhaled volume which was significantly greater than the jet (2.72+-0.98 ml vs 1.22+-0.59 ml, p <0.0001) for the three drugs. Regarding granulometry, the fraction of particles between 0.5 and 5 um, was higher with ultrasonic than with pneumatic nebulizer for tobramycine (67.1+-10.7 vs 55.5+-]1.5 %. p <0.001) and amiloride (66.4+-S1.2 % vs 58. l +-15%, p <0.05 %). The Variation of concentration due to nebulisation were independent of the type of apparatus but influenced by the drug since concentration was increased for tobramycine (+10.5+-18.6 %) and amiloride (+13.4+-8/9 %). In summary the effective fraction resulting from the inhalable fraction, from granulometry and from changes in concentration was significantly greater for ultrasonic than for jet nebrulizer (17.3+-6.7 % vs 9.7+-9.6 %, p <0.001). This study underlines the great variability of the performance of aerosols generators and therefore the need for an accurate evaluation of nebulizer performances in order to prescribe the best nebulizer/drug association in clinical practice.
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Submitted on : Friday, March 21, 2014 - 1:44:48 PM
Last modification on : Friday, September 2, 2022 - 5:14:29 PM


  • HAL Id : ineris-00962648, version 1
  • INERIS : PU-1996-024


F. Faurisson, J.F. Dessanges, Alain Grimfeld, Rémy Beaulieu, M.D. Kitzis, et al.. Etude comparative sur les performances et l'ergonomie de nébuliseurs dans la mucoviscidose. Revue des Maladies Respiratoires, 1996, 13 (2), pp.155-162. ⟨ineris-00962648⟩



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