Etude comparative sur les performances et l'ergonomie de nébuliseurs dans la mucoviscidose

Abstract : This study had, as its aim, to lest twelve nebulizers (6 jet, 6 ultrasonic) which are used in the treatment of cystic fibrosis. Devices were connected to a respirator in order to mimic the Ventilation of a child and of an adult suffering from cystis fibrosis. Three medications : tobramycine, colistine and amiloride were nebulised. The volume of the recommended solution varied between 1.5 and 13 ml according to the manufacturer. During a Session of ten minutes the ultrasonic nebulizer delivered an inhaled volume which was significantly greater than the jet (2.72+-0.98 ml vs 1.22+-0.59 ml, p <0.0001) for the three drugs. Regarding granulometry, the fraction of particles between 0.5 and 5 um, was higher with ultrasonic than with pneumatic nebulizer for tobramycine (67.1+-10.7 vs 55.5+-]1.5 %. p <0.001) and amiloride (66.4+-S1.2 % vs 58. l +-15%, p <0.05 %). The Variation of concentration due to nebulisation were independent of the type of apparatus but influenced by the drug since concentration was increased for tobramycine (+10.5+-18.6 %) and amiloride (+13.4+-8/9 %). In summary the effective fraction resulting from the inhalable fraction, from granulometry and from changes in concentration was significantly greater for ultrasonic than for jet nebrulizer (17.3+-6.7 % vs 9.7+-9.6 %, p <0.001). This study underlines the great variability of the performance of aerosols generators and therefore the need for an accurate evaluation of nebulizer performances in order to prescribe the best nebulizer/drug association in clinical practice.
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  • HAL Id : ineris-00962648, version 1
  • INERIS : PU-1996-024

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F. Faurisson, J.F. Dessanges, Alain Grimfeld, Rémy Beaulieu, M.D. Kitzis, et al.. Etude comparative sur les performances et l'ergonomie de nébuliseurs dans la mucoviscidose. Revue des Maladies Respiratoires, Elsevier Masson, 1996, 13 (2), pp.155-162. ⟨ineris-00962648⟩

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