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La modélisation en écotoxicologie

Abstract : We present a modelling framework to link effects on toxicological targets, effects on individuals and effects on populations in ecotoxicology. Our models first link exposure and effects on individuals. They couple toxicokinetics, to link exposure and body residues, with toxicodynamics, to assess how chemicals in the organism affect biological processes. They are based on the DEB (Dynamic Energy Budgets) theory by Kooijman (2000), which describes mathematically the assimilation and use of energy. They permit to assess the physiological mode of action of substances, and the effects of complex mixtures. We recently developed a Bayesian approach to estimate their parameters. The relevance of the analysis at individual level, with incorporation of time and modes of action, guarantees the relevance of the change of scale from individuals to population and of its use in ecotoxicological risk assessment. We studied population dynamics, and could balance the effects on population parameters by the influence of these parameters on the population dynamics. We also develop a modelling approach adapted to mesocosms to simulate control situations, which should increase the predictive power of these systems. The perspectives at INERIS are the development of biology-based models for endocrine disruption and the continuation of our works on the use of the change of scale in risk assessment and on mesocosms data analysis.
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Submitted on : Thursday, September 6, 2018 - 1:04:33 PM
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  • HAL Id : ineris-01869239, version 1



Alexandre R.R. Pery. La modélisation en écotoxicologie. Rapport Scientifique INERIS, 2009, 2008-2009, pp.21-23. ⟨ineris-01869239⟩



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