Population pharmacokinetic reanalysis of a Diazepam PBPK model: a comparison of Stan and GNU MCSim - Ineris - Institut national de l'environnement industriel et des risques Access content directly
Journal Articles Journal of Pharmacokinetics and Pharmacodynamics Year : 2019

Population pharmacokinetic reanalysis of a Diazepam PBPK model: a comparison of Stan and GNU MCSim

Abstract

The aim of this study is to benchmark two Bayesian software tools, namely Stan and GNU MCSim, that use different Markov chain Monte Carlo (MCMC) methods for the estimation of physiologically based pharmacokinetic (PBPK) model parameters. The software tools were applied and compared on the problem of updating the parameters of a Diazepam PBPK model, using time-concentration human data. Both tools produced very good fits at the individual and population levels, despite the fact that GNU MCSim is not able to consider multivariate distributions. Stan outperformed GNU MCSim in sampling efficiency, due to its almost uncorrelated sampling. However, GNU MCSim exhibited much faster convergence and performed better in terms of effective samples produced per unit of time.

Domains

Toxicology
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Dates and versions

ineris-03318105 , version 1 (09-08-2021)

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Cite

Periklis Tsiros, Frédéric Y. Bois, Aristides Dokoumetzidis, Georgia Tsiliki, Haralambos Sarimveis. Population pharmacokinetic reanalysis of a Diazepam PBPK model: a comparison of Stan and GNU MCSim. Journal of Pharmacokinetics and Pharmacodynamics, 2019, 46 (2), pp.173-192. ⟨10.1007/s10928-019-09630-x⟩. ⟨ineris-03318105⟩

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